How Excimer Laser Works
The excimer laser (or excimer lamp) delivers a focused beam of 308nm UVB light directly to the vitiligo
patch. Unlike full-body phototherapy (narrowband UVB), the excimer targets only the affected area, allowing
higher energy doses with faster results and less exposure to surrounding skin.
Excimer vs. Narrowband UVB
| Factor |
Excimer Laser |
Narrowband UVB |
| Target |
Individual patches only |
Entire body |
| Best for |
Small, localized patches |
Widespread vitiligo |
| Sessions to see results |
15–30 sessions |
30–60+ sessions |
| Frequency |
2–3 times/week |
2–3 times/week |
| Normal skin exposure |
Minimal |
Full body exposed |
Best Candidates for Excimer
- Patients with limited vitiligo — fewer than 10 patches or covering less than 10% body
surface
- Facial and neck patches — these areas respond particularly well
- Patients who cannot commit to full-body phototherapy sessions
- Children — targeted approach minimizes unnecessary UV exposure
Treatment Protocol
- Frequency: 2–3 sessions per week
- Session duration: 5–15 minutes (depends on number and size of patches)
- Initial response: Repigmentation dots may appear after 10–15 sessions
- Full course: 30–60 sessions typically
- Combination: Often used alongside topical tacrolimus for enhanced results
Realistic Outcomes
- Face and neck: 60–80% repigmentation achievable in many patients
- Trunk and limbs: 40–70% repigmentation
- Hands and feet: Most resistant — results are less predictable
- Some patches may not respond despite adequate treatment